Limited hepatitis B virus replication space in the chronically hepatitis C virus-infected liver.

نویسندگان

  • S F Wieland
  • S Asabe
  • R E Engle
  • R H Purcell
  • F V Chisari
چکیده

We compared the kinetics and magnitude of hepatitis B virus (HBV) infection in hepatitis C virus (HCV)-naive and chronically HCV-infected chimpanzees in whose livers type I interferon-stimulated gene (ISG) expression is strongly induced. HBV infection was delayed and attenuated in the HCV-infected animals, and the number of HBV-infected hepatocytes was drastically reduced. These results suggest that establishment of HBV infection and its replication space is limited by the antiviral effects of type I interferon in the chronically HCV-infected liver.

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عنوان ژورنال:
  • Journal of virology

دوره 88 9  شماره 

صفحات  -

تاریخ انتشار 2014